منابع مشابه
Imatinib metabolism and disposition in isolated rat perfused liver
Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
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Cadmium (Cd) is an important industrial and environmental toxicant with many industrial applications. Cd emissions to the atmospheric, aquatic, and terrestrial environment have increased during the last century. Since Cd is not degraded in the environment, the risk of human exposure is constantly increased due to Cd also enters to the food chain [1]. Humans are generally exposed to Cd by two ma...
متن کاملThiazolidinediones and liver toxicity.
Thiazolidinediones or glitazones specifically target insulin resistance. They have proven efficacy for reducing plasma glucose levels of type 2 diabetic patients treated with diet alone, sulphonylureas, metformin or insulin. In addition, they may be associated to some improvement of cardiovascular risk profile. However, troglitazone, the first compound approved by the FDA in the US, proved to b...
متن کاملimatinib metabolism and disposition in isolated rat perfused liver
imatinib is an orally administered tyrosine kinase inhibitor which inhibits the bcr-abl protein-tyrosine kinase with high selectivity. imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. the metabolism of imatinib is mediated by the cytochrome p450 (cyp) isoenzymes in the liver and gut wall. cgp74588 is a major active metabolite of ima...
متن کاملLiver Toxicity and Herbal Medicine
In the last few months there have been three letters in The Lancet, follow-up articles in most of the national newspapers including The Times and The Sunday Times, and discussions on the Jimmy Young Show on the toxicity of herbal medicines and a potential link with liver fatality. Subsequently, rumours have been spreading as to inherent dangers in herbal prescriptions and possible restrictions ...
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ژورنال
عنوان ژورنال: BMJ Case Reports
سال: 2018
ISSN: 1757-790X
DOI: 10.1136/bcr-2018-226740